|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Whole genome sequencing identified a second rare protein changing mutation of WIF1 that interacted with the HNRNPA0 variant resulting in extremely high risk for cancer in carriers of mutations in both genes (p = 1.98 × 10(-13)).
|
25716654 |
2015 |
|
Primary malignant neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Whole genome sequencing identified a second rare protein changing mutation of WIF1 that interacted with the HNRNPA0 variant resulting in extremely high risk for cancer in carriers of mutations in both genes (p = 1.98 × 10(-13)).
|
25716654 |
2015 |
|
Malignant tumor of cervix
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
While the WIF1 gene is characterized as a target for epigenetic silencing in some tumor types, WIF1 expression has not been examined in human cervical tissue and cervical cancer.
|
21873353 |
2011 |
|
Cervix carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
While the WIF1 gene is characterized as a target for epigenetic silencing in some tumor types, WIF1 expression has not been examined in human cervical tissue and cervical cancer.
|
21873353 |
2011 |
|
cervical cancer
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
While the WIF1 gene is characterized as a target for epigenetic silencing in some tumor types, WIF1 expression has not been examined in human cervical tissue and cervical cancer.
|
21873353 |
2011 |
|
Anorectal Malformations
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Western blot and real time RT-PCR revealed that Wif1 and β-catenin protein and mRNA expression level was significantly decreased in the ARM groups compared with the normal group on GD14 and GD15 (<i>p</i> < 0.05).
|
29507836 |
2018 |
|
Squamous cell carcinoma of esophagus
|
0.040 |
Biomarker
|
disease |
BEFREE |
We used methylation-specific polymerase chain reaction to detect hypermethylation of the promoter of four Wnt antagonists/inhibitors (SFRP-1, WIF-1, DKK-3 and RUNX3) using DNA from the plasma of ESCC patients (n = 81) and analyzed the association between promoter hypermethylation of Wnt pathway modulator genes and the two-year recurrence of ESCC.
|
22171134 |
2011 |
|
Malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We then studied WIF-1 expression in 18 freshly resected lung cancers, and we show a down-regulation in 15 of them (83%).
|
15256437 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We systematically screened FGFR3, PIK3CA, TP53, HRAS, NRAS and KRAS for mutations and quantitatively assessed the methylation status of APC, ARF, DBC1, INK4A, RARB, RASSF1A, SFRP1, SFRP2, SFRP4, SFRP5 and WIF1 in a prospective series of tumor biopsies (N = 105) and urine samples (N = 113) from 118 bladder tumor patients.
|
20824703 |
2011 |
|
Mixed Salivary Gland Tumor
|
0.020 |
AlteredExpression
|
disease |
LHGDN |
We screened 13 additional benign and malignant salivary gland tumors and detected WIF1 rearrangement in one out of two carcinomas ex-pleomorphic adenoma analyzed.
|
17171686 |
2007 |
|
Carcinoma
|
0.040 |
GeneticVariation
|
group |
BEFREE |
We screened 13 additional benign and malignant salivary gland tumors and detected WIF1 rearrangement in one out of two carcinomas ex-pleomorphic adenoma analyzed.
|
17171686 |
2007 |
|
Adenomatous Polyposis Coli
|
0.040 |
Biomarker
|
disease |
BEFREE |
We immunohistochemically examined various components of Wnt signaling pathway including β-catenin, tumor suppressor proteins, adenomatous polyposis coli (APC), and Axin, expression of naturally occurring pathway antagonists such as Dickkopf Wnt signaling pathway inhibitor 3 (DKK3), FRP2, and WIF1, as well as Wnt target cyclin D1 and c-Myc to establish if the pathway is constitutively activated in breast cancers arising in Saudi women.
|
29391809 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We immunohistochemically examined various components of Wnt signaling pathway including β-catenin, tumor suppressor proteins, adenomatous polyposis coli (APC), and Axin, expression of naturally occurring pathway antagonists such as Dickkopf Wnt signaling pathway inhibitor 3 (DKK3), FRP2, and WIF1, as well as Wnt target cyclin D1 and c-Myc to establish if the pathway is constitutively activated in breast cancers arising in Saudi women.
|
29391809 |
2018 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We identified recurrent mutations implicating a number of known and not previously identified genes and pathways in DLBCL including those related to chromatin modification (ARID1A and MEF2B), NF-κB (CARD11 and TNFAIP3), PI3 kinase (PIK3CD, PIK3R1, and MTOR), B-cell lineage (IRF8, POU2F2, and GNA13), and WNT signaling (WIF1).
|
23292937 |
2013 |
|
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
We hypothesized that downregulation of the Wnt inhibitory factor-1 (WIF-1) might be involved in the neoplastic progression of Barrett's esophagus (BE).
|
18005197 |
2008 |
|
Malignant neoplasm of urinary bladder
|
0.040 |
Biomarker
|
disease |
BEFREE |
We hypothesize that Wif-1 plays an important role in bladder cancer pathogenesis.
|
16428476 |
2006 |
|
Carcinoma of bladder
|
0.040 |
Biomarker
|
disease |
BEFREE |
We hypothesize that Wif-1 plays an important role in bladder cancer pathogenesis.
|
16428476 |
2006 |
|
Liver carcinoma
|
0.060 |
PosttranslationalModification
|
disease |
BEFREE |
We found that the sFRP1 gene encoding the subunit is a frequent target of aberrant DNA hypermethylation and silencing in HCC tumours, whereas other extracellular Wnt antagonists, WIF1 and Dkk3, exhibited no methylation in tumour cells, consistent with the notion that aberrant methylation events in cancer cells are non-randomly distributed among the genes and that there is a strong preference for hypermethylation of specific genes in HCC.
|
22351518 |
2012 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that restoration of WIF-1 inhibited the growth and proliferation of neuroblastoma cells in vitro.
|
24561119 |
2014 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that restoration of WIF-1 inhibited the growth and proliferation of neuroblastoma cells in vitro.
|
24561119 |
2014 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that restoration of WIF-1 inhibited the growth and proliferation of neuroblastoma cells in vitro.
|
24561119 |
2014 |
|
Thyroid Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found new characteristic of thyroid tumours: methylation of TP73, WIF1 and PDLIM4 TSGs, which can contribute to thyroid neoplasia.
|
31006665 |
2019 |
|
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We examined its effectiveness with NPY, PENK and WIF1, three biomarkers which we have previously shown to be of relevance to CRC.
|
26022272 |
2015 |
|
Adenoma
|
0.040 |
Biomarker
|
group |
BEFREE |
We discovered widespread hypermethylation of the Wnt antagonists SFRP1, SFRP2, SFRP5, DKK2, WIF1 and SOX17 in the transition from normal to adenoma with only the Wnt antagonists SFRP1, SFRP2, DKK2 and WIF1 showing further significant increase in methylation from adenoma to carcinoma.
|
25432628 |
2014 |
|
Malignant neoplasm of lung
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
We demonstrated previously that WIF-1 is silenced due to promoter hypermethylation in lung cancer cell lines.
|
19885602 |
2009 |